Abstract: There are two traditional numerical simulation methods of foam compound flooding: mechanism method and empirical method. The mechanism method is slow in operation, while the empirical method cannot reflect the reaction mechanism such as the formation and bursting of bubbles. In order to improve the calculation speed of numerical simulation of foam compound flooding, and reflect the role of parameters such as gas injection volume and half-life in foam compound flooding, this paper combines mechanism method and experience method, describes the embodiment of foam compound flooding in numerical simulation software in detail, conduct the indoor core displacement experiment to verify the reliability of the model, and predict the effect in Eh3 IV1–3 of Shuanghe oilfield. Numerical simulation results show that the relative error between recovery degree of the numerical simulated model by foam compound flooding and the experimental values is-4.54%, and the recovery of Eh3 IV1–3 is predicted to be enhanced 10.24%.