Abstract: Aiming at different effect of profile control measures at present and the reservoir suitability analysis only limited to the experimental results, based on the data of a large number of profile control measures in offshore oilfields, combining fuzzy comprehensive evaluation with mathematical statistics, the main factors and rules affecting the effect of profile control measures on offshore oilfield are obtained. The results show that profile control in positive rhythm reservoir is better than the anti-rhythm reservoir. Furthermore, the reservoir with permeability of 2 000×10~(-3)～3 500×10~(-3) μm~2, permeability variation 0.3 ～ 0.5, water cut 60% ～ 80%, recovery degree 0.45 ～ 0.60, water absorption coefficient variation 0.3 ～ 0.7, has better profile control effects. When the profile control measures are implemented for two rounds, the profile control effect is the best, and then the effect becomes worse gradually. The adaptability of profile control measures provides a basis for the optimization decision-making of profile control measures in offshore oilfields.