Abstract: According to three-dimensional seismic profiles of Qikou depression as the main basic information, and calculating paleo fall of the Shahejie formation section Ⅲ, section Ⅰ and Dongying formation sedimentary period. Nandagang fault activity has been analyzed. The results showed that the Nandagang fault activity is the strongest in Shahejie formation section Ⅰ sedimentary period, which did not show obvious tectonic migration, and the activity is different from the activity patterns of the study area, which resulted from the basement strike-slip faults. In addition, in the article, it is pointed out that the current Nandagang fault present formation was formed after Minghuazhen formation. Finally, it is discovered how the Nandagang fault affected the hydrocarbon generation, migration and accumulation and its significance.