Abstract: To improve production capacity and reduce sandstone reservoir damage in the process of oil and gas exploration in Lenghu area,northern margin of Qaidam Basin,through core flow experiment,the sensitivity characteristics of tight reservoir was studied,and the quantitative evaluation of the reservoir sensitivity was made.The experimental results show the reservoir had strong velocity sensitivity,strong water sensitivity and strong salt sensitivity,while the alkali sensitivity damage changed greatly,from non-alkali sensitive to strong alkali sensitivity and weak acid sensitivity.The sensitivity study provided a good guiding significance for oil and gas exploration and reservoir protection in this area.