Abstract: Interlayer interference coefficient is an very important parameter to confirm the limits of layer series combination and productivity evaluation.However,interlayer interference coefficient is difficult to decide because the parameter used for calculating it is hard to acquire.Then interlayer interference coefficient empirical value is usually used and some uncertainty is involved.This paper proposed using reservoir engineering method to calculate interlayer interference coefficient with DST test data,dynamic performance data,pressure buildup test interpretation results,PVT and core analysis results,and so on,when there is not interlayer interference well testing.The results of the oilfield application proved the method has good practicability and is easy to use.