Abstract: A compound grain plugging and profile control agent of GQ type is developed based on the geological characteristics of sandstone reservoirs with high permeability, high temperature and high salinity. This paper introduces the principles, properties, field operation process and effects of this new agent. The property indexes of this grain plugging and profile control agent are optimized. It is mainly used for water plugging in producers and injection profile control in water injectors in sandstone reservoirs with high permeability. It has the advantages of high efficiency, large temperature and salinity tolerance, long effective period and strong flushing resistance.