Abstract: H88 block E2d21 reservoir is a midium and low permeability reservoir dual controlled by the structure and lithology. The reservoir heterogeneity is serious on the upside, and crude oil with high saturation, high wax and high gas-oil ratio features. In the early stage, according to the petroleum geology features, reservoir numerical simulation has been applied, the development and injection patterns has been optimized to determine the limits of rational development policies, the early water injection has been implemented to maintain reservoir energy. In the process of development, the effective protection and rehabilitation measures reservoir has been implemented, and carried on timely separate layer water injection and dynamic allocation of water. After the water injection reservoir maintained a good development trend of high -speed and stable production. Production rate reach to 2. 88%, which is better than predictive value in the program.