Abstract: The Jiamuhe formation of Permian ,the major reservoir in the Bai-110 well block which is the priority appraisal area in Xinjiang Oilfield in recent years, are characterized by poor petrophysical property of matrix , strong anisotropy , complex rock components, which adds lots of difficulties to fracturing.there were two oil- wells couldn't be sand-fractured according to the design because the casing pressure overtook the surface pressure safety in 2008 which resulted in sand plug lowed than designed quantity . According to the analysis of Jiamuhe reservoir natural microfractures, the fracturing fluid loss is severe in fracturing, while the higher modulus to a narrow slit width, the role of mutual influence is easy to cause sand plug . To solve these problems by optimizing the fracture parameters, optimization of fracturing additive fluid and other technologies, the new fracturing design has been determined.In 2009, The research achievements have been shown by 11 wells in Jiamuhe formation with a success rate of 100% and high productivity for most of the fractured wells.