Abstract: In order to enhance the producing degree of low permeability reservoir,the water injection technology of simulated horizontal wells(large-scale fracturing of vertical wells)has been adopted.However,the effect of formation parameters and fracturing parameters on water injection of the simulated horizontal wells was not clear.Therefore,based on the geological data and production performance of a block in Shengli oilfield,a stochastic geological model was established and the study on main influencing factors of the simulated horizontal wells has been carried out.By using the single variable method and orthogonal experiment design method,different injection production parameter schemes have been established,and the corresponding development indexes of each scheme have been predicted by numerical simulation technology.Through range analysis and variance analysis,the qualitative analysis and quantitative study have been carried out to study the influence of formation permeability,crude oil viscosity,fracture angle,half crack length,fracture and formation permeability.The application results indicate the water injection development effect is good with the use of the simulated horizontal wells.