Abstract: The oil reservoir thickness is large,formation is from mid porous mid permeable to mid porous high permeable formation,the heterogeneity is more serious in Yangmuxi oilfield.After water injection,the injected water entered high permeable layer,caused small injected water wave and volume,which affected injection development seriously.According to the reservoir physical properties and current situa-tion,through a great deal of formula selection and simulation test,YM-1 high strength particles plugging agent and resin strong gel plugging agent has been developed.The indoor simulation test and field application of 3 Wells shows that these two kinds of agents effective blocked high permeable layer,strong erosion resistant,better onsite application and it can improve the injection development effect of Yan-muxi oilfield.