Abstract: Taking the 1-2 units in the second member of Sha-hejie Fm in block 2 of Shengtuo oilfield as examples, numerical reservoir simulation technologies are used to study the influences of interbed development on effects of water plugging and profile correction, and to analyze the impacts of relevant parameters on development effects, such as vertical permeability of reservoirs, well spacing range for profile correction and water plugging, and plugging rate. It provides a theoretical basis for more extensive application of this technology.