Abstract: The development of Gudong oilfield has entered the medium- high water bearing stage. Because of the long term action of waterflooding and erosion, the high permeability zone and high capacity channel become more popular in the subsurface reservoir, which will easily lead to the fluid channeling of concentrated polymer during the process of waterflooding. If this really happens, it is not only difficult to form high quality polymer slug, but also causes economic waste. According to the experiences in the past years, a series of profile control in depth with different water shutoff agents has been concluded, which respectively aims at special characteristics of oil-water wells in different stages of waterflooding. The result show that it has good effect for development