Abstract: As the main producing layers of small 10-16 block, Zao IV and Zao V, belong to low porosity and low permeability reservoir, with poor physical properties. If directly put into production, there must be a certain gap between geological proration. Therefore, fracturing stimulation should be carried out to achieve the purpose of efficient economic development. However, the reservoirs have the characteristics of deep depth, high temperature, long fracturing well section and strong water sensitivity, which brings new challenges for fracturing technology. In order to ensure effective fracturing stimulation, fracturing technology and fracturing fluid system should be optimized; the liquid nitrogen cleanup technology and pressure mining group as a string technology should be adopted, and then multilayers stimulation at one time can be realized. The application shows good increased effect, with average initial daily liquid of 24.9 m3 and daily oil of 20.4 t.