Abstract: The abnormal high pressure formation in Niger delta severely affected safe drilling operation.The special geological condition that the lost circulation point and over flow formation exist in the same section has brought big challenges for kill well operation.The reason and mechanism for the formation of abnormal high pressure in Niger delta was discussed and the pressure prediction model was presented based on actual drilling and logging data of completed wells in A block.The real time pressure during drilling can be predicted by adopting the prediction model combined with the real time drilling and logging data to detect the abnormal high pressure timely.A case for actual drilling abnormal high pressure in A block was analyzed,detailed and countermeasure for drilling abnormal high pressure formation was suggested.