Abstract: In the process of oilfield development, the optimization study of injection-production pressure system is one of the key links in reservoir research of water drive development. Based on reservoir engineering calculation method, a relational chart for judging the rationality of injection-production pressure system is created, that is, on the basis of giving full play to oil well productivity, considering injection-production balance relationship, taking fracture pressure and permissible pressure of water injection equipment as restrictive conditions, the wellhead and bottom hole pressures of water injection wells at different water cut stages are calculated. Meantime, the curve chart of the corresponding relationship between water injection pressure and oil well production under different formation pressure levels, development stages and injectionproduction ratios are constructed to intuitively determine the rationality of injection-production pressure system. The application results show that this method can accurately identify the rationality and safety of injection-production pressure system in the oilfield, meet the actual production demand of oil field, and provide reference for the study of pressure system of different types of water drive reservoir.