Abstract: Based on data collected from various sources and theories of petroleum geology,this paper analyzes petroleum geology characteristics and hydrocarbon enrichment regularities,and predicts the exploration favorable areas in the middle Magdalena basin.The marine limestone and mudstone of late Cretaceous La Luna formation is the major source rock,and the Cenozoic continental sandstone is the dominant reservoir.Therefore,the middle Magdalena basin mainly formed the hydrocarbon storage pattern as lower generation and upper accumulations.Structural traps and structural combination traps are widely developed in the basin.Oil and gas aremainly accumulated in the Eocene- Oligocene ChorrosChuspas group sandstones,which developed adjacent to regional paleo-highs,faults and unconformities.Faults are the principal factors that control the formation and distribution of hydrocarbon in the middle Magdalena basin.The over-thrust fault belt in the eastern and southern margin,unconformities in the west slope and central uplifts comprise the most promising areas. Meanwhile,the stratigraphic traps in the slope also have good exploration potential.