Abstract: Qiaokou area in Dongpu depression with an exploration and development history over 30 years has a high average exploration level while small proved reserves. Reevaluation of oil and gas resources has renewed knowledge of reservoir conditions. It is discovered that Qioakou structure is bounded by Yuhuangmiao fault with a nearly WE trend and the northern and southern oil sources come from different oil generating sags. Combination of source rock, reservoir rock and cap rock in deep series of strata is rational, thus they are the favorable horizon for oil and gas accumulation. There are three favorable zones for progressive exploration and development: the step zone of Huanghe fault, the reverse roof zones in the upthrown blocks of Yuhuangmiao fault and Litun fault. Structure interpretation and reservoir prediction are performed through stereo structure interpretation, visualization interpretation, section slice jointing and high resolution formation reversion. All of the 8 progressive exploration and development wells have gave out commercial oil flow.