Abstract: Fluvial facies is widespread in Shengli oildom in Neogene,which has preserved rich oil & gas resources.Through comparison and analysis of sedimentary strata,tectonic setting,oil and gas generation and migration and accumulation conditions of Dongying and Zhanhua depression,hydrocarbon accumulation potential difference of Guantao formation has been studied.It is considered that,accommodation space changes of Zhanhua depression is larger than Dongying depression,which is caused by tectonic subsidence.As a result,Guantao formation of Zhanhua is thicker,with deeper water and strong heterogeneity sandbody.Because of the weaker fault system at Paleogene in Zhanhua,traps with reservoirs are less,most of the oil and gas migrated through sandbody,unconformity and faults to Guantao formation,which is like a blanket.In the end,favorable exploration target of Dongying depression is forecasted.