Abstract: After many years of production,ZJ2-1U oil reservoir of Wenchang-A oilfield has entered the high water-cut stage and how to control water distribution and stable oil production has become the big problem at present.Aiming at the characteristics of irregular well pattern,less data and high quality of 3D seismic data,closed coring well data can be fully applied.In combination with gamma,acoustic and neutron logging data,first of all,the interlayer insulation can be identified from closed coring well.Secondly,from the coring well,the non-coring wells can be calibrated,and by using neural network algorithm,the interlayer insulation of non-coring wells can be identified.Then by using wellseismic combination method of sedimentary facies and gamma inversion data volume and with the method of sequential indicator,the interlayer between the wells and in3 D spatial distribution can be predicted.Finally,combined the dynamic and static,the impact of the interlayer insulation on the development effect can be revealed,which can provide the guidance for residual oil extraction and increase oil field recovery.